Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20976884 | 0.98 | MAPT (0.51) | RAB9ANPC1MAPTHIF1AKDM4E | |
| SCHEMBL194980 | 0.88 | SIRT6 (0.49) | RAB9ANPC1MAPTHIF1AKDM4E | |
| SCHEMBL1890774 | 0.87 | SIRT6 (0.61) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16609018 | 0.86 | SIRT6 (0.47) | RAB9AMAPTKDM4ESMN1; SMN2SIRT6 | |
| SCHEMBL20580169 | 0.86 | PRKDC (0.55) | RAB9ANPC1MAPTHIF1AKDM4E | |
| SCHEMBL17893656 | 0.86 | SIRT6 (0.44) | RAB9ANPC1MAPTHIF1AKDM4E | |
| SCHEMBL7652198 | 0.86 | ACVR1 (0.47) | MAPTKDM4ESIRT6ALDH1A1MEN1 | |
| SCHEMBL5233625 | 0.86 | SIRT6 (0.44) | RAB9ANPC1MAPTKDM4ESIRT6 | |
| SCHEMBL16599909 | 0.85 | SIRT6 (0.46) | RAB9AMAPTKDM4ESMN1; SMN2SIRT6 | |
| SCHEMBL30195159 | 0.85 | MAPT (0.50) | RAB9AMAPTKDM4ESMN1; SMN2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048306-A1 | NOVEL AGENTS TARGETING CYP51 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |