Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28663853 | 1.00 | TRPV1 (0.57) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16610404 | 0.89 | TRPV1 (0.49) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28012613 | 0.89 | TRPV1 (0.60) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16610369 | 0.89 | TRPV1 (0.60) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16610335 | 0.86 | TRPV1 (0.47) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16610336 | 0.86 | TRPV1 (0.52) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28012614 | 0.86 | TRPV1 (0.52) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16610330 | 0.84 | TRPV1 (0.47) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16610379 | 0.81 | TRPV1 (0.51) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20573033 | 0.81 | TRPV1 (0.51) | TRPV1KDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107011313-B | Application of substituted cinnamide derivative in preparation of anxiolytic drugs | 天士力医药集团股份有限公司 | 2021-11-30 | — | — | CN | claimed |
| EP-3409664-B1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS | TASLY PHARMACEUTICAL GROUP CO (CN) | 2021-01-06 | — | — | EP | claimed |
| US-20190046500-A1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATION | TASLY PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-02-14 | — | — | US | claimed |
| EP-3409664-A1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS | Tasly Pharmaceutical Group Co., Ltd. (CN) | 2018-12-05 | — | — | EP | claimed |
| CN-107011313-B | Application of substituted cinnamide derivative in preparation of anxiolytic drugs | 天士力医药集团股份有限公司 | 2021-11-30 | — | — | CN | disclosed |
| EP-3409664-B1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS | TASLY PHARMACEUTICAL GROUP CO (CN) | 2021-01-06 | — | — | EP | disclosed |
| EP-3409664-B1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS | TASLY PHARMACEUTICAL GROUP CO (CN) | 2021-01-06 | — | — | EP | disclosed |
| US-10874636-B2 | Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication | TASLY PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-12-29 | — | — | US | disclosed |
| US-10874636-B2 | Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication | TASLY PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-12-29 | — | — | US | disclosed |
| US-20190046500-A1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATION | TASLY PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-02-14 | — | — | US | disclosed |
| US-20190046500-A1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATION | TASLY PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-02-14 | — | — | US | disclosed |
| EP-3409664-A1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS | Tasly Pharmaceutical Group Co., Ltd. (CN) | 2018-12-05 | — | — | EP | disclosed |
| WO-2015043522-A1 | TRIFLUOROMETHYL-CONTAINING AMIDE ALKALOID, MANUFACTURING METHOD AND PHARMACEUTICAL USE THEREOF | 天士力制药集团股份有限公司 | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874636-B2 | Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication | CBR3, CYP4F3, CYP4F2 | TRPV1 1447/4885KDM4E 2036/4885ALDH1A1 862/4885 |
| US-20190046500-A1 | APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATION | CBR3, CYP4F3, CYP4F2 | TRPV1 1447/4885KDM4E 2036/4885ALDH1A1 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.