Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863417 | 1.00 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL25222723 | 1.00 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL21256945 | 0.84 | PIK3C3 (0.50) | PIK3C3 | |
| SCHEMBL26515061 | 0.84 | PIK3C3 (0.50) | PIK3C3 | |
| SCHEMBL22296388 | 0.83 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL24681517 | 0.83 | MTOR (0.50) | PIK3C3 | |
| SCHEMBL24681530 | 0.83 | MTOR (0.50) | PIK3C3 | |
| SCHEMBL22296389 | 0.83 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL22296387 | 0.83 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL25018626 | 0.83 | MTOR (0.50) | PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | ATHENEX, INC. | 2021-07-01 | — | — | US | disclosed |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | ATHENEX, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2019-05-02 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
| CN-104507940-B | Heterocyclic compounds | 武田药品工业株式会社 | 2017-01-25 | — | — | CN | disclosed |
| US-20160251352-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2016-09-01 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-20150141406-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |
| CN-104507940-A | Heterocyclic compounds | TAKEDA PHARMACEUTICAL | 2015-04-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251352-A1 | HETEROCYCLIC COMPOUND | JAK2, JAK1, STAT3 | PIK3C3 564/4885 |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885 |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885 |
| US-20150141406-A1 | HETEROCYCLIC COMPOUND | JAK2, JAK1, STAT3 | PIK3C3 564/4885 |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885 |
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.