Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 4/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16610761 | 0.83 | MAPK8 (0.34) | KCNJ5KCNJ3MAPK8ALDH1A1POLB | |
| SCHEMBL16611192 | 0.79 | KCNJ5 (0.39) | KCNJ5KCNJ3MAPK1ALDH1A1SCN9A | |
| SCHEMBL16611334 | 0.78 | RORC (0.46) | KCNJ5KCNJ3SCN9A | |
| SCHEMBL16611388 | 0.77 | NPSR1 (0.40) | KCNJ5KCNJ3SCN9AMETNTRK1 | |
| SCHEMBL16610793 | 0.77 | RORC (0.40) | KCNJ5KCNJ3SCN9ABRAFNTRK1 | |
| SCHEMBL16611463 | 0.76 | KCNJ5 (0.37) | KCNJ5KCNJ3ROCK2ROCK1 | |
| SCHEMBL16611435 | 0.76 | KCNJ5 (0.42) | KCNJ5KCNJ3GRM2 | |
| SCHEMBL16611950 | 0.76 | RORC (0.44) | KCNJ5KCNJ3SCN9ANTRK1 | |
| SCHEMBL16611320 | 0.74 | LRRK2 (0.50) | MET | |
| SCHEMBL16610870 | 0.74 | KCNJ5 (0.41) | KCNJ5KCNJ3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160251352-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2016-09-01 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-20150141406-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251352-A1 | HETEROCYCLIC COMPOUND | JAK2, JAK1, STAT3 | KCNJ5 2242/4885KCNJ3 2857/4885MAPK8 46/4885 |
| US-20150141406-A1 | HETEROCYCLIC COMPOUND | JAK2, JAK1, STAT3 | KCNJ5 2242/4885KCNJ3 2857/4885MAPK8 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.