Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.68 |
| ▸ | BRAF | P15056 | 9/20 | 0.61 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | ABL1 | P00519 | 3/20 | 0.61 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 1/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660855 | 0.91 | RAF1 (0.82) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL1660319 | 0.90 | BRAF (0.54) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL1660403 | 0.89 | BRAF (0.68) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL1660265 | 0.88 | ABL1 (0.57) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL1659561 | 0.88 | RAF1 (0.61) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL1659057 | 0.86 | MAPK14 (0.75) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL18191221 | 0.85 | RAF1 (0.76) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL14911164 | 0.83 | ABL1 (0.73) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL2332335 | 0.83 | RAF1 (0.61) | RAF1BRAFKDRABL1DDR2 | |
| SCHEMBL19878527 | 0.82 | KDR (0.81) | RAF1BRAFKDRABL1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |