Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | RASGRP3 | Q8IV61 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL28085459 | 0.83 | CYP3A4 (0.92) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL2538164 | 0.83 | CYP3A4 (0.68) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL27474785 | 0.83 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL16371573 | 0.83 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL29362146 | 0.83 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL15174 | 0.83 | CYP3A4 (1.00) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL8394882 | 0.82 | TSHR (0.60) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| Propene SCHEMBL28124828 | 0.82 | CYP3A4 (0.89) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| Ethylene SCHEMBL11883084 | 0.81 | CYP3A4 (0.96) | CYP3A4TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL11394440 | 0.81 | CYP3A4 (0.96) | CYP3A4TSHRALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11958822-B2 | Treprostinil derivative compounds and methods of using same | Corsair Pharma, Inc. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230331691-A1 | TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME | Corsair Pharma, Inc. | 2023-10-19 | — | — | US | disclosed |
| US-11505535-B2 | Treprostinil derivative compounds and methods of using same | Corsair Pharma, Inc. (US) | 2022-11-22 | — | — | US | disclosed |
| US-11046666-B2 | Treprostinil derivative compounds and methods of using same | Corsair Pharma, Inc. (US) | 2021-06-29 | — | — | US | disclosed |
| EP-3428206-B1 | CURABLE COMPOSITION COMPRISING AN ACRYLIC-MODIFIED ALKYD RESIN AND COATING MATERIAL FOR PRIMING FOR THIN INORGANIC FILM | DAINIPPON INK & CHEMICALS (JP) | 2021-06-23 | — | — | EP | disclosed |
| US-11026920-B2 | Use of NK-1 receptor antagonist serlopitant in pruritus | VYNE THERAPEUTICS INC. (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3828160-A1 | TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME | Corsair Pharma, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| CN-108779220-B | Acrylic modified alkyd resin and coating agent for inorganic material film prime coat | DIC株式会社 | 2021-03-30 | — | — | CN | disclosed |
| US-20200306224-A1 | USE OF NK-1 RECEPTOR ANTAGONIST SERLOPITANT IN PRURITUS | VYNE THERAPEUTICS INC. | 2020-10-01 | — | — | US | disclosed |
| US-10781316-B2 | Acrylic-modified alkyd resin and coating material for priming for thin inorganic film | DIC CORPORATION (JP) | 2020-09-22 | — | — | US | disclosed |
| US-5744512-A | Coreactive photoinitiators | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-04-28 | — | — | US | disclosed |
| US-5532112-A | PHOTOPOLYMERIZATION | CIBA-GEIGY CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| US-5071732-A | TWO-LAYER SYSTEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-12-10 | — | — | US | disclosed |
| US-4922004-A | Copolymerizable photoinitiators | Merck Patent Gesellschaft mit bescrankter Haftung (DE) | 1990-05-01 | — | — | US | disclosed |
| US-4914004-A | RADIATION CURABLE; IMMOBILIZED PHOTOINITIATOR | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-03 | — | — | US | disclosed |
| US-4822682-A | Oriented polymer materials | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-04-18 | — | — | US | disclosed |
| US-4496447-A | PHOTOPOLYMERIZATION OF UNSATURATED COMPOUNDS AND FOR CURING PRINTING INKS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1985-01-29 | — | — | US | disclosed |
| US-4434035-A | Mixtures of aromatic-aliphatic ketones as photoinitiators and photopolymerizable systems containing them | Merck Patent Gesellschaft mit beschr/a/ nkter Haftung (DE) | 1984-02-28 | — | — | US | disclosed |
| US-4390453-A | DISCOLORATION INHIBITION; ULTRAVIOLET HARDENING OF ACRYLIC INKS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-06-28 | — | — | US | disclosed |
| US-4374984-A | Aromatic-aliphatic ketones useful as photoinitiators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11505535-B2 | Treprostinil derivative compounds and methods of using same | PTGIS, PTGIR, PTGER3 | CYP3A4 75/4885TSHR 927/4885ALDH1A1 1619/4885 |
| US-20230331691-A1 | TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME | PTGIS, PTGIR, PTGER3 | CYP3A4 75/4885TSHR 927/4885ALDH1A1 1619/4885 |
| US-20200306224-A1 | USE OF NK-1 RECEPTOR ANTAGONIST SERLOPITANT IN PRURITUS | TACR1, CYSLTR1, NPSR1 | CYP3A4 849/4885TSHR 1250/4885ALDH1A1 2186/4885 |
| US-11958822-B2 | Treprostinil derivative compounds and methods of using same | PTGIS, PTGIR, PTGER3 | CYP3A4 75/4885TSHR 927/4885ALDH1A1 1619/4885 |
| US-11026920-B2 | Use of NK-1 receptor antagonist serlopitant in pruritus | TACR1, CYSLTR1, NPSR1 | CYP3A4 849/4885TSHR 1250/4885ALDH1A1 2186/4885 |
| US-11046666-B2 | Treprostinil derivative compounds and methods of using same | PTGIS, PTGIR, PTGER3 | CYP3A4 75/4885TSHR 927/4885ALDH1A1 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.