PTGIS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL9765884	1.00	15/20
SCHEMBL9765888	0.85	15/20
SCHEMBL9765942	0.84	15/20
SCHEMBL9723983	0.84	15/20
SCHEMBL9160822	0.72	15/20
SCHEMBL9161390	1.00	14/20
SCHEMBL9163044	1.00	14/20
SCHEMBL9723953	1.00	14/20
SCHEMBL9765891	1.00	14/20
SCHEMBL9765876	0.89	14/20
SCHEMBL9765944	0.89	14/20
SCHEMBL9765871	0.88	14/20
SCHEMBL9162585	0.79	14/20
SCHEMBL10337122	0.68	14/20
SCHEMBL12676131	0.66	14/20
SCHEMBL10337091	0.54	14/20
SCHEMBL3518900	1.00	13/20
SCHEMBL3518907	1.00	13/20
SCHEMBL9035683	1.00	13/20
SCHEMBL9765895	0.85	13/20

Clinical trials — most relevant to PTGIS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)	PHASE4	COMPLETED
Type 2 Diabetes Mellitus and Atherosclerosis	PHASE4	UNKNOWN
Bosentan in Treatment of Pulmonary Arterial Hypertension	PHASE4	COMPLETED
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function	PHASE4	UNKNOWN
WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW-ACS)	PHASE4	COMPLETED
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes	PHASE3	UNKNOWN
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs	PHASE3	COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia	PHASE2/PHASE3	UNKNOWN
Aspirin Versus Clopidogrel Effect on Uterine Blood Flow in Women With Unexplained Recurrent Miscarriages	PHASE2/PHASE3	UNKNOWN
Addition of Aspirin to Standard of Care in Oral Cancer	PHASE2/PHASE3	COMPLETED
Inhaled Iloprost, Dynamic Hyperinflation, and Oxidative Stress in COPD Patients	PHASE2	COMPLETED
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease	PHASE2	COMPLETED
Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial	PHASE2	COMPLETED
Celebrex for Pain Relief After Oral Surgery	PHASE2	COMPLETED
Vascular Effects of Endothelium-Derived Versus Hemoglobin-Transported Nitric Oxide in Healthy Subjects	PHASE1	COMPLETED
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A	nan	ACTIVE_NOT_RECRUITING
OrthoCor Advanced Trial for Knee Osteoarthritis	nan	COMPLETED
Gap Junction Potentiation of Endothelial Function With Rotigaptide	nan	COMPLETED
The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients	nan	COMPLETED
Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture	nan	UNKNOWN
Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient	nan	COMPLETED
Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium	nan	COMPLETED
Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates	nan	RECRUITING
A Prospective Study to Evaluate the Effect of Chronic Nitrate Therapy on Vasodilation Function in Coronary Heart Disease	nan	UNKNOWN
Study About Patients Using Copper Intrauterine Device	nan	COMPLETED
Palmitoylethanolamide in Ulcerative Colitis	nan	NOT_YET_RECRUITING
Core Stability vs. Traditional Physical Therapy: A Comparative Study on Alleviating Low Back Pain in Dysmenorrhea	nan	ENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a PTGIS binder may also engage these)

Protein	Name	Similarity
Q29626	—	1.000	Q29626 →
O35074	—	0.997	O35074 →
Q62969	—	0.991	Q62969 →
O88962	—	0.978	O88962 →
CYP8B1	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	0.978	landscape →
Q7YRB2	—	0.977	Q7YRB2 →
P46634	—	0.976	P46634 →
O02766	—	0.975	O02766 →
CYP7A1	Cytochrome P450 7A1	0.972	landscape →
Q64505	—	0.972	Q64505 →
P18125	—	0.972	P18125 →
O46491	—	0.971	O46491 →
Q9JKJ9	—	0.969	Q9JKJ9 →
P51542	—	0.969	P51542 →
P10612	—	0.967	P10612 →
P00189	—	0.966	P00189 →
O46515	—	0.966	O46515 →
CYP27A1	Sterol 26-hydroxylase, mitochondrial	0.966	landscape →
P17177	—	0.966	P17177 →
Q9PUB4	—	0.966	Q9PUB4 →
CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial	0.966	landscape →
P30099	—	0.965	P30099 →
P97720	—	0.965	P97720 →
F1RE08	—	0.964	F1RE08 →
P15393	—	0.964	P15393 →
CYP7B1	Cytochrome P450 7B1	0.963	landscape →
Q9NYL5	—	0.963	Q9NYL5 →
Q64658	—	0.963	Q64658 →
P30100	—	0.962	P30100 →
O55127	—	0.962	O55127 →