Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 15/20 | 0.72 |
| ▸ | TUBB | P07437 | 15/20 | 0.72 |
| ▸ | TUBA3C | P0DPH7 | 15/20 | 0.72 |
| ▸ | TUBA1B | P68363 | 15/20 | 0.72 |
| ▸ | TUBA4A | P68366 | 15/20 | 0.72 |
| ▸ | TUBB4B | P68371 | 15/20 | 0.72 |
| ▸ | TUBB3 | Q13509 | 15/20 | 0.72 |
| ▸ | TUBB2A | Q13885 | 15/20 | 0.72 |
| ▸ | TUBB8 | Q3ZCM7 | 15/20 | 0.72 |
| ▸ | TUBA3E | Q6PEY2 | 15/20 | 0.72 |
| ▸ | TUBA1A | Q71U36 | 15/20 | 0.72 |
| ▸ | TUBA1C | Q9BQE3 | 15/20 | 0.72 |
| ▸ | TUBB6 | Q9BUF5 | 15/20 | 0.72 |
| ▸ | TUBB2B | Q9BVA1 | 15/20 | 0.72 |
| ▸ | TUBB1 | Q9H4B7 | 15/20 | 0.72 |
| ▸ | EGFR | P00533 | 9/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.72 |
| ▸ | KDR | P35968 | 9/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22432529 | 0.89 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16611787 | 0.85 | TUBB4A (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16622703 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16612445 | 0.83 | TUBB4A (0.72) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16612695 | 0.79 | TUBB4A (0.76) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16612578 | 0.79 | TUBB4A (0.76) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16612144 | 0.78 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16622677 | 0.78 | TUBB4A (0.89) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL17837006 | 0.78 | PDGFRB (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18551428 | 0.78 | TUBB4A (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751884-B2 | N-aryl unsaturated fused ring tertiary amine compounds, preparation method and anti-tumor applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-09-05 | — | — | US | claimed |
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-21 | — | — | US | claimed |
| EP-2857393-A1 | N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF | Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A. (CN) | 2015-04-08 | — | — | EP | claimed |
| US-9751884-B2 | N-aryl unsaturated fused ring tertiary amine compounds, preparation method and anti-tumor applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-09-05 | — | — | US | disclosed |
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-21 | — | — | US | disclosed |
| EP-2857393-A1 | N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF | Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A. (CN) | 2015-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | H1-0, H1-5, H1-3 | TUBB4A 1798/4885TUBB 1401/4885TUBA3C 1692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.