Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.77 |
| ▸ | CYBB | P04839 | 5/20 | 0.77 |
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.77 |
| ▸ | NOX5 | Q96PH1 | 4/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612805 | 0.90 | NOX4 (0.72) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL16612522 | 0.88 | NOX4 (0.75) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL16612222 | 0.87 | NOX4 (0.74) | NOX4CYBBNOX1NOX5CYP3A4 | |
| Setanaxib SCHEMBL1302603 | 0.87 | NOX4 (1.00) | NOX4CYBBNOX1NOX5CYP3A4 | |
| Setanaxib SCHEMBL29362127 | 0.87 | NOX4 (1.00) | NOX4CYBBNOX1NOX5CYP3A4 | |
| Setanaxib SCHEMBL29375704 | 0.87 | NOX4 (1.00) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL16612701 | 0.86 | NOX4 (0.59) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL14931735 | 0.86 | NOX4 (0.72) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL29523003 | 0.86 | NOX4 (0.72) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL1302943 | 0.85 | NOX4 (0.72) | NOX4CYBBNOX1NOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049655-A1 | COMPOUNDS USEFUL FOR THE TREATMENT OF PDE5 INHIBITOR-POORLY RESPONSIVE ERECTILE DYSFUNCTION | GENKYOTEX SA (CH) | 2015-04-09 | — | — | WO | claimed |
| EP-2857399-A1 | Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction | GenKyoTex SA (CH) | 2015-04-08 | — | — | EP | claimed |
| EP-2857399-A1 | Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction | GenKyoTex SA (CH) | 2015-04-08 | — | — | EP | disclosed |
| EP-2857399-A1 | Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction | GenKyoTex SA (CH) | 2015-04-08 | — | — | EP | disclosed |