Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 7/20 | 0.55 |
| ▸ | KYAT3 | Q6YP21 | 3/20 | 0.55 |
| ▸ | KYAT1 | Q16773 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847936 | 0.86 | AADAT (0.55) | AADATKYAT3KYAT1ALDH1A1 | |
| SCHEMBL3783110 | 0.85 | AADAT (0.56) | AADATKYAT3KYAT1GPR119 | |
| SCHEMBL3783795 | 0.81 | AADAT (0.60) | AADATKYAT3KYAT1 | |
| SCHEMBL3778808 | 0.80 | AADAT (0.65) | AADATKYAT3KYAT1SMN1; SMN2POLB | |
| SCHEMBL3770746 | 0.78 | AADAT (0.61) | AADATKYAT3KYAT1 | |
| SCHEMBL3784387 | 0.78 | AADAT (0.56) | AADATKYAT3KYAT1 | |
| SCHEMBL6763386 | 0.77 | AADAT (0.74) | AADATKYAT3KYAT1 | |
| SCHEMBL3777393 | 0.77 | AADAT (0.73) | AADATKYAT3KYAT1 | |
| SCHEMBL3778920 | 0.76 | AADAT (0.59) | AADATKYAT3KYAT1 | |
| SCHEMBL3781828 | 0.76 | AADAT (0.65) | AADATKYAT3KYAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | disclosed |