Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 19/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202169 | 0.82 | PIK3CA (0.60) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 | |
| SCHEMBL1445147 | 0.80 | PIK3R1 (0.73) | PIK3CAPIK3R1 | |
| SCHEMBL1445083 | 0.80 | PIK3R1 (1.00) | PIK3CAPIK3R1PIK3CD | |
| SCHEMBL632385 | 0.79 | PIK3CA (0.77) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 | |
| SCHEMBL12819811 | 0.79 | PIK3R1 (0.70) | PIK3CAPIK3R1PIK3CD | |
| SCHEMBL5555180 | 0.77 | PIK3CA (0.63) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 | |
| SCHEMBL5555182 | 0.77 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 | |
| SCHEMBL20458892 | 0.77 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 | |
| SCHEMBL15603105 | 0.76 | PIK3CA (0.72) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 | |
| SCHEMBL14725951 | 0.76 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CDKCNH2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480549-B1 | Fused imidazo[3,2-d]pyrazines as PI3 kinase inhibitors | FUNDACIÓN CT NAC DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2015-04-08 | — | — | EP | disclosed |