Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.46 |
| ▸ | MTOR | P42345 | 6/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613045 | 0.77 | PIK3CA (0.35) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL114392 | 0.73 | PIK3CA (0.81) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL114387 | 0.63 | PIK3CA (0.80) | PIK3CAMTOR | |
| SCHEMBL169800 | 0.62 | PIK3CA (0.60) | PIK3CAMTOR | |
| SCHEMBL16612783 | 0.62 | PIK3CA (0.45) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL114698 | 0.61 | PIK3CA (0.81) | PIK3CAMTOR | |
| SCHEMBL114558 | 0.61 | PIK3CA (0.80) | PIK3CAMTOR | |
| SCHEMBL166335 | 0.60 | PIK3CA (0.63) | PIK3CAMTOR | |
| SCHEMBL16613065 | 0.59 | PIK3CA (0.43) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL115796 | 0.58 | PIK3CA (0.80) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | claimed |