Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30077107 | 0.89 | HSD11B1 (0.60) | HSD11B1HRH3ACKR3DRD2PARP1 | |
| SCHEMBL15347391 | 0.89 | HSD11B1 (0.60) | HSD11B1HRH3ACKR3DRD2PARP1 | |
| SCHEMBL30076916 | 0.84 | HSD11B1 (0.51) | HSD11B1HRH3 | |
| SCHEMBL15347424 | 0.84 | HSD11B1 (0.51) | HSD11B1HRH3 | |
| SCHEMBL15347563 | 0.83 | HSD11B1 (0.50) | HSD11B1HRH3 | |
| SCHEMBL30077118 | 0.83 | HSD11B1 (0.50) | HSD11B1HRH3 | |
| SCHEMBL12469472 | 0.83 | HSD11B1 (0.55) | HSD11B1HRH3ACKR3PARP1 | |
| SCHEMBL1091465 | 0.83 | HSD11B1 (0.77) | HSD11B1HRH3PARP1 | |
| SCHEMBL2591980 | 0.82 | HSD11B1 (1.00) | HSD11B1CD38 | |
| SCHEMBL15347405 | 0.81 | HSD11B1 (0.49) | HSD11B1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627649-B1 | CXCR4 RECEPTOR ANTAGONISTS | PROXIMAGEN LTD (GB) | 2015-04-08 | — | — | EP | claimed |