Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 18/20 | 0.60 |
| ▸ | KYAT3 | Q6YP21 | 4/20 | 0.56 |
| ▸ | KYAT1 | Q16773 | 3/20 | 0.56 |
| ▸ | GOT1 | P17174 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786012 | 0.96 | AADAT (0.62) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3775992 | 0.88 | AADAT (0.62) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3775113 | 0.85 | AADAT (0.62) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL5132076 | 0.82 | AADAT (0.65) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3775097 | 0.76 | AADAT (0.68) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL6763551 | 0.76 | AADAT (0.58) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3781672 | 0.76 | AADAT (0.68) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL6763283 | 0.76 | AADAT (1.00) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL2125876 | 0.76 | AADAT (1.00) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL7423257 | 0.76 | AADAT (1.00) | AADATKYAT3KYAT1GOT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | disclosed |