Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264590 | 0.92 | HPGD (0.52) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL3988734 | 0.76 | NPSR1 (0.61) | HPGDATMNPSR1KDM4EALDH1A1 | |
| SCHEMBL13739801 | 0.75 | ALDH1A1 (0.60) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL11664468 | 0.73 | ALDH1A1 (0.53) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL2875179 | 0.73 | AKT2 (0.50) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL29956253 | 0.73 | HPGD (0.49) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL27376029 | 0.73 | HPGD (0.49) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL17214888 | 0.73 | GRK6 (0.48) | HPGDNPSR1KDM4EALDH1A1RAB9A | |
| SCHEMBL7617054 | 0.71 | CDK8 (0.57) | HPGDATMNPSR1KDM4ELMNA | |
| SCHEMBL10784410 | 0.71 | NPSR1 (0.51) | HPGDATMNPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 615 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2939541-A1 | HERBICIDE SAFENER COMBINATION | Bayer Intellectual Property GmbH (DE) | 2015-11-04 | — | — | EP | claimed |
| WO-2011138280-A2 | HERBICIDE/SAFENER COMBINATIONS COMPRISING ARYLPYRIDAZINONES AND SAFENER | BAYER CROPSCIENCE AG (DE) | 2011-11-10 | — | — | WO | claimed |
| EP-2369927-A2 | HERBICIDE-SAFENER COMBINATION | Bayer CropScience AG (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-2369931-A2 | HERBICIDE/SAFENER COMBINATION | Bayer CropScience AG (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-2369922-A2 | HERBICIDE-SAFENER COMBINATION | Bayer CropScience AG (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-2369929-A2 | HERBICIDE-SAFENER COMBINATION | Bayer CropScience AG (DE) | 2011-10-05 | — | — | EP | claimed |
| EP-2210492-A1 | Herbicide safener combination | Bayer CropScience AG (DE) | 2010-07-28 | — | — | EP | claimed |
| WO-2010060578-A2 | HERBICIDE/SAFENER COMBINATION | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | WO | claimed |
| WO-2010060581-A2 | HERBICIDE-SAFENER COMBINATION | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | WO | claimed |
| WO-2010060580-A2 | HERBICIDE-SAFENER COMBINATION | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | WO | claimed |
| WO-2010060579-A2 | HERBICIDE-SAFENER COMBINATION | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | WO | claimed |
| EP-2191720-A1 | Herbicide-safener combination | Bayer CropScience AG (DE) | 2010-06-02 | — | — | EP | claimed |
| EP-2191719-A1 | Herbicide safener combination | Bayer CropScience AG (DE) | 2010-06-02 | — | — | EP | claimed |
| EP-2191716-A1 | Herbicide safener combination | Bayer CropScience AG (DE) | 2010-06-02 | — | — | EP | claimed |
| EP-3668845-B1 | HERBICIDALLY ACTIVE 3-PHENYL-5-TRIFLUORMETHYLISOXAZOLIN-5-CARBOXAMIDES OF CYCLOPENTYL CARBOXYLIC ACIDS AND ESTERS | BAYER AG (DE) | 2024-06-26 | — | — | EP | disclosed |
| WO-2024104956-A1 | SUBSTITUTED CYCLOALKYLSULFANYLPHENYLURACILS AND THEIR SALTS, AND THEIR USE AS HERBICIDAL ACTIVE SUBSTANCES | BAYER AKTIENGESELLSCHAFT (DE) | 2024-05-23 | — | — | WO | disclosed |
| WO-2024104952-A1 | SUBSTITUTED CYCLOPROPYLOXYPHENYLURACILS AND SALTS THEREOF, AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES | BAYER AKTIENGESELLSCHAFT (DE) | 2024-05-23 | — | — | WO | disclosed |
| WO-1993000010-A1 | NEW MIXTURES OF HERBICIDES AND ANTIDOTES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-01-07 | — | — | WO | disclosed |
| EP-0521407-A1 | New mixtures of herbicides and antidotes | Hoechst Schering AgrEvo GmbH (DE) | 1993-01-07 | — | — | EP | disclosed |
| EP-0492367-A2 | Mixtures of herbicides and antidotes | Hoechst Schering AgrEvo GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |