Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 12/20 | 0.61 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518787 | 0.90 | PRKAA2 (0.76) | PRKAA2CXCR3PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL10284160 | 0.89 | OPRM1 (0.49) | PRKAA2OPRM1OPRK1CACNA1H | |
| SCHEMBL518014 | 0.76 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL10284157 | 0.75 | PRKAA2 (0.69) | PRKAA2CXCR3PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL12266507 | 0.75 | PRKAA2 (0.73) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL517451 | 0.71 | PRKAA2 (1.00) | PRKAA2CXCR3PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL10284154 | 0.69 | PRKAA2 (0.80) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL22268938 | 0.69 | PRKAA2 (0.89) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL27739981 | 0.69 | OPRM1 (0.68) | PRKAA2CXCR3PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL10284164 | 0.69 | PRKAA2 (0.86) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048547-A2 | METHODS FOR USING AND BIOMARKERS FOR AMPK-ACTIVATING COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | disclosed |