Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661826 | 0.88 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL1661618 | 0.87 | S1PR1 (0.58) | S1PR1S1PR3TP53MGLL | |
| SCHEMBL1661614 | 0.75 | S1PR1 (0.75) | S1PR1S1PR3 | |
| SCHEMBL1662062 | 0.74 | S1PR1 (0.79) | S1PR1S1PR3 | |
| SCHEMBL1660276 | 0.74 | ADORA3 (0.44) | S1PR1S1PR3 | |
| SCHEMBL1661212 | 0.72 | S1PR1 (0.50) | S1PR1S1PR3 | |
| SCHEMBL1661678 | 0.71 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL1661831 | 0.71 | S1PR1 (0.80) | S1PR1S1PR3 | |
| SCHEMBL1664089 | 0.71 | S1PR1 (0.54) | S1PR1S1PR3 | |
| SCHEMBL1662108 | 0.71 | S1PR1 (0.54) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |