Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.42 |
| ▸ | KDM5A | P29375 | 4/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18365944 | 0.80 | KDM4C (0.47) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL30587480 | 0.80 | KDM4C (0.47) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL15957010 | 0.78 | KDM4C (0.65) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL18940460 | 0.76 | KDM4C (0.43) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL3688462 | 0.75 | KDM4C (0.57) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL1661165 | 0.75 | PTGER1 (0.41) | — | |
| SCHEMBL23188813 | 0.73 | KDM4C (0.46) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL21314995 | 0.73 | KDM4C (0.50) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL30504034 | 0.73 | KDM4C (0.50) | KDM4CKDM5AKDM5BKDM4ARBP4 | |
| SCHEMBL7078593 | 0.73 | KDM4C (0.48) | KDM4CKDM5AKDM5BKDM4ARBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-B1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC (US) | 2013-08-14 | — | — | EP | claimed |
| US-7842685-B2 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-11-30 | — | — | US | claimed |
| US-20100029611-A1 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-02-04 | — | — | US | claimed |
| EP-2306994-B1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC (US) | 2013-08-14 | — | — | EP | disclosed |
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| US-7842685-B2 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20100029611-A1 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029611-A1 | S1P1 receptor agonists and use thereof | S1PR1, S1PR5, S1PR2 | KDM4C 3924/4885KDM5A 2584/4885KDM5B 2549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.