Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661196 | 0.89 | S1PR1 (0.39) | S1PR1MAOBS1PR3 | |
| SCHEMBL1661806 | 0.86 | S1PR1 (0.56) | S1PR1S1PR3 | |
| SCHEMBL1661765 | 0.85 | S1PR1 (0.41) | S1PR1MAOBS1PR3 | |
| SCHEMBL1662093 | 0.83 | S1PR1 (0.43) | S1PR1MAOBS1PR3 | |
| SCHEMBL1661615 | 0.83 | MAOB (0.40) | S1PR1MAOBS1PR3 | |
| SCHEMBL1661097 | 0.82 | S1PR1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL1661867 | 0.79 | S1PR1 (0.38) | S1PR1MAOBS1PR3 | |
| SCHEMBL1661460 | 0.79 | S1PR1 (0.38) | S1PR1MAOB | |
| SCHEMBL1661749 | 0.78 | MAOB (0.39) | S1PR1MAOBS1PR3 | |
| SCHEMBL1661564 | 0.76 | S1PR1 (0.50) | S1PR1MAOBS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |