Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847924 | 1.00 | MEN1 (0.53) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL30762080 | 1.00 | MEN1 (0.53) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL30762040 | 0.84 | MEN1 (0.50) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL1813116 | 0.83 | GAA (0.49) | MEN1KMT2AALDH1A1MAPTAAK1 | |
| SCHEMBL1813115 | 0.83 | GAA (0.49) | MEN1KMT2AALDH1A1MAPTAAK1 | |
| SCHEMBL5928301 | 0.82 | MEN1 (0.51) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL28911009 | 0.81 | MEN1 (0.50) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL14493754 | 0.80 | AAK1 (0.54) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL1067740 | 0.79 | MEN1 (0.46) | MEN1KMT2ANPC1PIN1ALDH1A1 | |
| SCHEMBL1067741 | 0.79 | MEN1 (0.46) | MEN1KMT2ANPC1PIN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592071-B1 | Tricyclic heterocyclic compounds | BRISTOL MYERS SQUIBB CO (US) | 2019-09-18 | — | — | EP | disclosed |
| US-9216972-B2 | Tricyclic heterocyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-8987495-B2 | Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-03-24 | — | — | US | disclosed |
| US-8987495-B2 | Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-03-24 | — | — | US | disclosed |
| US-20140012016-A1 | DIAMINO ACID DERIVATIVE STARTING MATERIAL, MANUFACTURING METHOD THEREOF, AND DIAMINO ACID DERIVATIVE MANUFACTURING METHOD | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-01-09 | — | — | US | disclosed |
| US-20140012016-A1 | DIAMINO ACID DERIVATIVE STARTING MATERIAL, MANUFACTURING METHOD THEREOF, AND DIAMINO ACID DERIVATIVE MANUFACTURING METHOD | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-01-09 | — | — | US | disclosed |
| US-8563765-B2 | Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2013-10-22 | — | — | US | disclosed |
| US-8563765-B2 | Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2013-10-22 | — | — | US | disclosed |
| EP-2306994-B1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC (US) | 2013-08-14 | — | — | EP | disclosed |
| EP-2592071-A1 | Tricyclic heterocyclic compounds | Bristol-Myers Squibb Company (US) | 2013-05-15 | — | — | EP | disclosed |
| US-20120214767-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2012-08-23 | — | — | US | disclosed |
| US-8168658-B2 | Inhibitors of histone deacetylase | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| WO-2011059784-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20110071310-A1 | DIAMINO ACID DERIVATIVE STARTING MATERIAL, MANUFACTURING METHOD THEREOF, AND DIAMINO ACID DERIVATIVE MANUFACTURING METHOD | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-03-24 | — | — | US | disclosed |
| US-7842685-B2 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20100029611-A1 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME LLC | 2009-03-12 | — | — | US | disclosed |
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140012016-A1 | DIAMINO ACID DERIVATIVE STARTING MATERIAL, MANUFACTURING METHOD THEREOF, AND DIAMINO ACID DERIVATIVE MANUFACTURING METHOD | DAO, DDC, DCTD | MEN1 473/4885KMT2A 280/4885NPC1 3710/4885 |
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC6 | MEN1 2325/4885KMT2A 60/4885NPC1 3227/4885 |
| US-20100029611-A1 | S1P1 receptor agonists and use thereof | S1PR1, S1PR5, S1PR2 | MEN1 684/4885KMT2A 3037/4885NPC1 332/4885 |
| US-20120214767-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | S1PR1, S1PR3, TBXA2R | MEN1 880/4885KMT2A 3948/4885NPC1 936/4885 |
| US-20110071310-A1 | DIAMINO ACID DERIVATIVE STARTING MATERIAL, MANUFACTURING METHOD THEREOF, AND DIAMINO ACID DERIVATIVE MANUFACTURING METHOD | DAO, DDC, DCTD | MEN1 473/4885KMT2A 280/4885NPC1 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.