Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 12/20 | 0.60 |
| ▸ | SCN2B | O60939 | 4/20 | 0.53 |
| ▸ | SCN1B | Q07699 | 4/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.53 |
| ▸ | SCN1A | P35498 | 3/20 | 0.53 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618535 | 0.82 | SCN9A (0.52) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL31331542 | 0.79 | SCN9A (0.64) | SCN9AP4HTMPTPN1 | |
| SCHEMBL17946819 | 0.78 | SCN9A (0.57) | SCN9ASCN5A | |
| Hydrochloric Acid SCHEMBL5704194 | 0.78 | SCN9A (0.54) | SCN9A | |
| SCHEMBL16600419 | 0.78 | ROCK1 (0.59) | ROCK2ROCK1 | |
| SCHEMBL29707122 | 0.77 | ESR2 (0.58) | ESR2PTPN1 | |
| SCHEMBL121338 | 0.77 | ESR2 (0.58) | ESR2PTPN1 | |
| SCHEMBL17946822 | 0.77 | SCN9A (0.67) | SCN9ASCN5A | |
| Hydrochloric Acid SCHEMBL16600645 | 0.77 | ROCK1 (0.58) | ROCK2ROCK1 | |
| SCHEMBL438531 | 0.77 | PTPRC (0.59) | ESR2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |