Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.46 |
| ▸ | SCN2B | O60939 | 2/20 | 0.46 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5943863 | 0.83 | HDAC6 (0.61) | CA12CA1CA9HDAC8HDAC6 | |
| SCHEMBL16618532 | 0.82 | SCN9A (0.60) | SCN9AP4HTMSCN5ASCN2BSCN1B | |
| SCHEMBL31331542 | 0.82 | SCN9A (0.64) | SCN9AMAP4K4P4HTMPTPN1 | |
| SCHEMBL364110 | 0.77 | HDAC3 (0.58) | SCN9ACA12CA1CA9P4HTM | |
| Hydrochloric Acid SCHEMBL5704204 | 0.76 | SCN9A (0.45) | SCN9ABCL2BAK1MAP4K4SCN5A | |
| SCHEMBL14285959 | 0.76 | PTPN1 (0.69) | HDAC8HDAC6PTPN1 | |
| Hydrochloric Acid SCHEMBL4438185 | 0.76 | P4HTM (0.56) | SCN9ACA12CA1CA9P4HTM | |
| SCHEMBL279954 | 0.76 | HDAC1 (0.63) | SCN9AP4HTMHDAC6PTPN1 | |
| SCHEMBL679956 | 0.75 | MAPK14 (0.55) | SCN9AP4HTMSCN5ASCN2BSCN1B | |
| SCHEMBL680184 | 0.75 | PTGS2 (0.53) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |