Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.57 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065774 | 0.84 | PTPN1 (0.61) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL732581 | 0.83 | TGM2 (0.61) | ALDH1A1CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL4903618 | 0.82 | TGM2 (0.61) | ALDH1A1PTPN1CYP2C9CYP2C19MAPT | |
| SCHEMBL4582840 | 0.82 | PTPN1 (0.63) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL4808309 | 0.81 | PTPN1 (0.61) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL30791550 | 0.81 | PTPN1 (0.61) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL951041 | 0.81 | PTPN1 (0.61) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL9540198 | 0.81 | PTPN1 (0.58) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL7462472 | 0.79 | PTPN1 (0.60) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 | |
| SCHEMBL16594594 | 0.79 | PTPN1 (0.56) | ALDH1A1PTPN1ACKR3CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160214963-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Beyond Oncology Pharmaceutical LLC (US) | 2016-07-28 | — | — | US | disclosed |
| US-20160214963-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Beyond Oncology Pharmaceutical LLC (US) | 2016-07-28 | — | — | US | disclosed |
| US-20160214963-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Beyond Oncology Pharmaceutical LLC (US) | 2016-07-28 | — | — | US | disclosed |
| WO-2015050703-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHEN YI (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015050703-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHEN YI (US) | 2015-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214963-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, SYK | ALDH1A1 3076/4885PTPN1 127/4885ACKR3 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.