Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
| ▸ | SORD | Q00796 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28564917 | 0.84 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL18435733 | 0.79 | MAPK1 (0.38) | SMN1; SMN2ALDH1A1MAPK1POLBLMNA | |
| SCHEMBL18179064 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MAPK1POLBRXFP1 | |
| SCHEMBL24387170 | 0.76 | MAPT (0.40) | SMN1; SMN2ALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL8582659 | 0.73 | ALDH1A1 (0.33) | ALDH1A1KMT2AAPLNR | |
| SCHEMBL20844100 | 0.70 | — | — | |
| SCHEMBL311281 | 0.70 | — | — | |
| SCHEMBL25560063 | 0.69 | PLAU (0.33) | — | |
| SCHEMBL17820266 | 0.69 | ALDH1A1 (0.35) | ALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL25559859 | 0.69 | NTRK1 (0.44) | SMN1; SMN2ALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488514-A1 | INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR | Proximagen Limited (GB) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045353-A1 | INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR | PROXIMAGEN LIMITED (GB) | 2011-04-21 | — | — | WO | disclosed |