Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720556 | 0.84 | KCNQ3 (0.47) | ELANECACNA1HTUBB1PLA2G10PLA2G2A | |
| SCHEMBL2119201 | 0.83 | TUBB1 (0.56) | ELANEPOLBTUBB1LMNAALDH1A1 | |
| SCHEMBL2651525 | 0.82 | PIM1 (0.47) | ELANETUBB1PLA2G10PLA2G2APIM1 | |
| SCHEMBL24110372 | 0.80 | TUBB1 (0.39) | ELANECACNA1HTUBB1PLA2G10PLA2G2A | |
| SCHEMBL2116459 | 0.79 | TFPI2 (0.47) | ELANEPOLBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL24110386 | 0.78 | MAOA (0.39) | ELANECACNA1HTUBB1PLA2G10PLA2G2A | |
| SCHEMBL24110343 | 0.78 | MAOA (0.39) | ELANECACNA1HTUBB1PLA2G10PLA2G2A | |
| SCHEMBL24110340 | 0.78 | MAOA (0.39) | ELANECACNA1HTUBB1PLA2G10PLA2G2A | |
| SCHEMBL2115772 | 0.77 | CA12 (0.44) | ELANELMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7483288 | 0.76 | PRKCI (0.47) | ELANELMNASMN1; SMN2KDM4EMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | Pfizer Inc. (US) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015049616-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | WO | disclosed |