Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.57 |
| ▸ | CCNC | P24863 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18933448 | 0.79 | MAP4K4 (0.52) | PDE10AMAP4K4SUV39H2PIM1PIM3 | |
| SCHEMBL18890155 | 0.79 | MAP4K4 (0.52) | PDE10AMAP4K4SUV39H2PIM1PIM3 | |
| SCHEMBL15272489 | 0.79 | MAP4K4 (0.49) | PDE10AMAP4K4SUV39H2CKS1BSKP1 | |
| SCHEMBL15272486 | 0.79 | MAP4K4 (0.49) | PDE10AMAP4K4SUV39H2CKS1BSKP1 | |
| SCHEMBL17296051 | 0.78 | MEN1 (0.55) | PDE10AMAP4K4SUV39H2CKS1BSKP1 | |
| SCHEMBL17296049 | 0.78 | MEN1 (0.55) | PDE10AMAP4K4SUV39H2CKS1BSKP1 | |
| SCHEMBL25888902 | 0.78 | SUV39H2 (0.52) | PDE10AMAP4K4SUV39H2PIM1PIM3 | |
| SCHEMBL17295997 | 0.78 | PDE10A (0.52) | PDE10AMAP4K4SUV39H2PIM1PIM3 | |
| SCHEMBL18933447 | 0.78 | PDE10A (0.52) | PDE10AMAP4K4SUV39H2PIM1PIM3 | |
| SCHEMBL18890144 | 0.78 | PDE10A (0.52) | PDE10AMAP4K4SUV39H2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| US-20150045255-A1 | Endometrial Phase or Endometrial Cancer Biomarkers | WALFISH, PAUL (CA) | 2015-02-12 | — | — | US | disclosed |