Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 10/20 | 0.67 |
| ▸ | CDK8 | P49336 | 10/20 | 0.67 |
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16629154 | 0.84 | CCNC (0.62) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL18228251 | 0.82 | CCNC (0.53) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL27834290 | 0.82 | CCNC (0.53) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL20445941 | 0.82 | CCNC (0.57) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL16620510 | 0.82 | CCNC (0.53) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL16620237 | 0.81 | CDK8 (1.00) | CCNCCDK8 | |
| SCHEMBL16629102 | 0.81 | CDK8 (1.00) | CCNCCDK8 | |
| SCHEMBL16620231 | 0.81 | CDK8 (1.00) | CCNCCDK8 | |
| SCHEMBL15360084 | 0.79 | HRH4 (0.54) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL16622459 | 0.79 | HRH4 (0.64) | CCNCCDK8HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |