Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 11/20 | 0.62 |
| ▸ | CDK8 | P49336 | 11/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228315 | 0.87 | PDE10A (0.55) | CCNCCDK8PDE10AHRH4HRH3 | |
| SCHEMBL1587934 | 0.86 | HRH4 (0.67) | CCNCCDK8PDE10AHRH4HRH3 | |
| SCHEMBL28219652 | 0.86 | JAK3 (0.55) | PDE10AMAP4K4 | |
| SCHEMBL16620602 | 0.86 | MAP4K4 (0.59) | CCNCCDK8PDE10AMAP4K4 | |
| SCHEMBL16620599 | 0.86 | MAP4K4 (0.59) | CCNCCDK8PDE10AMAP4K4 | |
| SCHEMBL1588740 | 0.86 | JAK3 (0.55) | PDE10AMAP4K4 | |
| SCHEMBL16629090 | 0.86 | JAK3 (0.55) | PDE10AMAP4K4 | |
| SCHEMBL16620125 | 0.84 | CCNC (0.67) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL18228321 | 0.81 | GPR119 (0.59) | CCNCCDK8PDE10AMAP4K4 | |
| SCHEMBL7239787 | 0.81 | SYK (0.56) | PDE10AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |