Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.41 |
| ▸ | CDK2 | P24941 | 9/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386934 | 0.83 | BTK (0.51) | BTK | |
| SCHEMBL23830989 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL18228083 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL27834290 | 0.80 | CCNC (0.53) | CCNCCDK8BTK | |
| SCHEMBL16620510 | 0.80 | CCNC (0.53) | CCNCCDK8BTK | |
| SCHEMBL18228251 | 0.80 | CCNC (0.53) | CCNCCDK8BTK | |
| SCHEMBL2329427 | 0.79 | GPBAR1 (0.44) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL18890120 | 0.77 | GLS (0.53) | — | |
| SCHEMBL31402759 | 0.76 | SMO (0.42) | CDK2PANK3 | |
| SCHEMBL31402767 | 0.76 | SMO (0.42) | CDK2PANK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| US-20150045255-A1 | Endometrial Phase or Endometrial Cancer Biomarkers | WALFISH, PAUL (CA) | 2015-02-12 | — | — | US | disclosed |