Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 14/20 | 0.78 |
| ▸ | CDK8 | P49336 | 14/20 | 0.78 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | BPTF | Q12830 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16620489 | 1.00 | CCNC (0.78) | CCNCCDK8CA12CA1CA2 | |
| SCHEMBL16629102 | 0.88 | CDK8 (1.00) | CCNCCDK8BPTF | |
| SCHEMBL16620237 | 0.88 | CDK8 (1.00) | CCNCCDK8BPTF | |
| SCHEMBL16620231 | 0.88 | CDK8 (1.00) | CCNCCDK8BPTF | |
| SCHEMBL16620517 | 0.85 | CDK8 (1.00) | CCNCCDK8CA12CA1CA2 | |
| SCHEMBL16629099 | 0.85 | CDK8 (1.00) | CCNCCDK8CA12CA1CA2 | |
| SCHEMBL16620519 | 0.85 | CDK8 (1.00) | CCNCCDK8CA12CA1CA2 | |
| SCHEMBL20445941 | 0.79 | CCNC (0.57) | CCNCCDK8BTK | |
| SCHEMBL16620028 | 0.76 | CDK8 (0.80) | CCNCCDK8BPTF | |
| SCHEMBL16620147 | 0.76 | CDK8 (0.80) | CCNCCDK8BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | claimed |
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |