Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 16/20 | 1.00 |
| ▸ | CCNC | P24863 | 15/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 0.68 |
| ▸ | CA1 | P00915 | 2/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.68 |
| ▸ | CA4 | P22748 | 2/20 | 0.68 |
| ▸ | CA7 | P43166 | 2/20 | 0.68 |
| ▸ | CA9 | Q16790 | 2/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16629099 | 1.00 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16620517 | 1.00 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16619951 | 0.88 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16629089 | 0.88 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16619956 | 0.88 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16620484 | 0.85 | CCNC (0.78) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16620489 | 0.85 | CCNC (0.78) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16620076 | 0.77 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL16620435 | 0.77 | CDK8 (1.00) | CDK8CCNCCA12CA1CA2 | |
| SCHEMBL29777510 | 0.76 | NTRK1 (1.00) | CDK8CCNCCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | claimed |
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| US-20150045255-A1 | Endometrial Phase or Endometrial Cancer Biomarkers | WALFISH, PAUL (CA) | 2015-02-12 | — | — | US | disclosed |