Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495620 | 0.96 | SMN1; SMN2 (0.67) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL30309475 | 0.85 | NR1H2 (0.51) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL15688210 | 0.85 | NR1H2 (0.51) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL2961101 | 0.85 | KDM4E (0.49) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL922214 | 0.85 | CYP2A13 (0.61) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL15542251 | 0.85 | NR1H2 (0.67) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL34464853 | 0.82 | ACHE (0.49) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL22172323 | 0.82 | NR1H2 (0.52) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL22172215 | 0.82 | NR1H2 (0.49) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 | |
| SCHEMBL2010740 | 0.82 | ACHE (0.65) | KDM4ESMN1; SMN2ACHEALDH1A1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| US-20150045255-A1 | Endometrial Phase or Endometrial Cancer Biomarkers | WALFISH, PAUL (CA) | 2015-02-12 | — | — | US | disclosed |