Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628073 | 0.85 | CA12 (0.59) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL11001590 | 0.84 | EPHX2 (0.81) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL16786359 | 0.83 | MAPT (0.65) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL16628034 | 0.82 | MAPT (0.60) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL4113855 | 0.82 | RAB9A (0.79) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL2681462 | 0.82 | MAPT (0.78) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL11008406 | 0.81 | CA12 (0.56) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL16628060 | 0.81 | CA12 (0.66) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL17664318 | 0.80 | EPHX2 (0.81) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL16620818 | 0.80 | NAMPT (0.61) | MAPTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |