Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16622109 | 1.00 | CYP1A2 (0.58) | CYP1A2CYP2D6HIF1ALMNAKDM4E | |
| SCHEMBL13741859 | 1.00 | CYP1A2 (0.58) | CYP1A2CYP2D6HIF1ALMNAKDM4E | |
| SCHEMBL7496186 | 0.92 | CYP1A2 (0.59) | CYP1A2CYP2D6HIF1ALMNAKDM4E | |
| SCHEMBL1520497 | 0.90 | CYP1A2 (0.57) | CYP1A2CYP2D6HIF1ALMNAKDM4E | |
| SCHEMBL22519226 | 0.87 | CYP1A2 (0.50) | CYP1A2CYP2D6HIF1ALMNAKDM4E | |
| SCHEMBL6447740 | 0.86 | CYP2D6 (0.50) | CYP1A2CYP2D6HIF1ALMNAMEN1 | |
| SCHEMBL16600897 | 0.82 | IDO1 (0.53) | CYP1A2CYP2D6HIF1A | |
| SCHEMBL7085986 | 0.81 | CYP2D6 (0.49) | CYP1A2CYP2D6HIF1ALMNAMEN1 | |
| SCHEMBL6267837 | 0.79 | HTR2A (0.44) | CYP1A2CYP2D6HIF1AL3MBTL1 | |
| SCHEMBL23536506 | 0.79 | SLC18A3 (0.45) | CYP1A2CYP2D6HIF1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9572854-B2 | Treatment of protein degradation disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-02-21 | — | — | US | disclosed |
| US-8999289-B2 | Treatment of protein degradation disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-04-07 | — | — | US | disclosed |