Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17609122 | 1.00 | SLC18A3 (0.45) | SLC18A3SIGMAR1IGF1RMEN1KMT2A | |
| SCHEMBL13275902 | 0.91 | IDO1 (0.45) | SLC18A3SIGMAR1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL14782621 | 0.81 | SLC18A3 (0.45) | SLC18A3SIGMAR1IGF1RMEN1KMT2A | |
| SCHEMBL868087 | 0.80 | AOC3 (0.46) | — | |
| SCHEMBL16622109 | 0.79 | CYP1A2 (0.58) | MEN1KMT2ACYP1A2CYP2D6HIF1A | |
| SCHEMBL13741859 | 0.79 | CYP1A2 (0.58) | MEN1KMT2ACYP1A2CYP2D6HIF1A | |
| SCHEMBL16622110 | 0.79 | CYP1A2 (0.58) | MEN1KMT2ACYP1A2CYP2D6HIF1A | |
| SCHEMBL20289657 | 0.77 | ADRB2 (0.41) | CYP1A2CYP2D6HIF1A | |
| SCHEMBL20289658 | 0.77 | ABAT (0.39) | CYP1A2CYP2D6HIF1A | |
| SCHEMBL21799143 | 0.77 | ADRB2 (0.41) | CYP1A2CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |