Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.51 |
| ▸ | RAF1 | P04049 | 11/20 | 0.51 |
| ▸ | CSF1R | P07333 | 11/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.51 |
| ▸ | ARAF | P10398 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12433866 | 0.89 | CSF1R (0.53) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL2314140 | 0.88 | CSF1R (0.52) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL2314933 | 0.87 | BRAF (0.53) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL19072915 | 0.84 | CSF1R (0.49) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL2312453 | 0.84 | CSF1R (0.50) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL14728020 | 0.84 | MELK (0.51) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL12432541 | 0.83 | RAF1 (0.57) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL2364820 | 0.82 | LMNA (0.58) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL2313222 | 0.82 | CSF1R (0.66) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL2310995 | 0.82 | BRAF (0.54) | BRAFRAF1CSF1RDDR2DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999973-B2 | Thieno[3,2-d]pyrimidine derivatives having inhibitory activity on protein kinases | HANMI SCIENCE CO., LTD (KR) | 2015-04-07 | — | — | US | disclosed |