Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.67 |
| ▸ | DRD2 | P14416 | 5/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.67 |
| ▸ | DRD3 | P35462 | 5/20 | 0.67 |
| ▸ | HTR2A | P28223 | 4/20 | 0.67 |
| ▸ | HRH1 | P35367 | 4/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.67 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.67 |
| ▸ | HTR2B | P41595 | 3/20 | 0.67 |
| ▸ | MTOR | P42345 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desipramine SCHEMBL29379525 | 0.81 | SLC6A4 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL5072939 | 0.81 | SLC6A4 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL34384 | 0.81 | SLC6A4 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL29085912 | 0.80 | SLC6A4 (0.97) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL41992 | 0.80 | SLC6A2 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL2944786 | 0.80 | SLC6A2 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL5501781 | 0.80 | SLC6A2 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL29364790 | 0.80 | SLC6A2 (1.00) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| Desipramine SCHEMBL41993 | 0.79 | SLC6A4 (0.94) | SLC6A2SLC6A4CHRM2CHRM1DRD2 | |
| SCHEMBL25835838 | 0.76 | SETD7 (0.37) | SLC6A2SLC6A4CHRM2CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012793-B1 | USE OF A TRICYCLIC COMPOUND FOR PREPARING A MEDICAMENT FOR TREATING SKELETAL MUSCLE DEGENERATION OF GENETIC ORIGIN | ASS FRANÇAISE CONTRE LES MYOPATHIES (FR) | 2015-04-08 | — | — | EP | disclosed |