Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18872334 | 0.87 | HTT (0.37) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL31497522 | 0.84 | HTT (0.38) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL173687 | 0.84 | HTT (0.38) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL25509748 | 0.84 | HTT (0.41) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL25888930 | 0.82 | MEN1 (0.37) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL20073784 | 0.81 | HTT (0.43) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL16794437 | 0.81 | MEN1 (0.40) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL23562252 | 0.77 | HTT (0.34) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL16814201 | 0.77 | HTT (0.39) | HTTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL20445710 | 0.77 | HTT (0.39) | HTTMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611798-B1 | PYRIDAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT INC (US) | 2015-04-08 | — | — | EP | disclosed |