Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13418989 | 0.66 | — | — | |
| SCHEMBL12281360 | 0.66 | ACHE (0.31) | ALDH1A1TSHRTDP1 | |
| SCHEMBL16622959 | 0.66 | — | — | |
| SCHEMBL6469941 | 0.66 | TDP1 (0.33) | ALDH1A1TDP1POLBPKM | |
| SCHEMBL20977414 | 0.62 | — | — | |
| SCHEMBL9638790 | 0.61 | MAPT (0.49) | MAPTKMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL5922524 | 0.60 | KMT2A (0.50) | MAPTKMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL1024700 | 0.60 | MAPT (0.61) | MAPTKMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL4619073 | 0.59 | KAT2B (0.51) | MAPTKMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL11022003 | 0.59 | MAPT (0.59) | MAPTKMT2AALDH1A1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |