Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.74 |
| ▸ | FYN | P06241 | 14/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.69 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.69 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.69 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | FGR | P09769 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945398 | 0.92 | FYN (0.74) | PIM1FYNNTRK1NTRK3NTRK2 | |
| SCHEMBL16623011 | 0.88 | FYN (0.77) | PIM1FYNNTRK1NTRK3NTRK2 | |
| SCHEMBL13223339 | 0.85 | MKNK1 (0.71) | PIM1FYNNTRK1NTRK3NTRK2 | |
| SCHEMBL136986 | 0.85 | PIM1 (1.00) | PIM1FYNRETPDGFRBFLT3 | |
| SCHEMBL23683338 | 0.85 | FYN (0.76) | FYNNTRK1NTRK3NTRK2MKNK1 | |
| SCHEMBL13234624 | 0.85 | FYN (1.00) | PIM1FYNABL1 | |
| SCHEMBL2950182 | 0.85 | FYN (1.00) | PIM1FYN | |
| SCHEMBL16622996 | 0.84 | NTRK1 (0.74) | PIM1FYNNTRK1NTRK3NTRK2 | |
| SCHEMBL2949419 | 0.84 | FYN (0.82) | PIM1FYNMKNK1 | |
| SCHEMBL2947613 | 0.84 | FYN (0.80) | PIM1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857404-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE AS KINASE INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2015-04-08 | — | — | EP | disclosed |