Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 6/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.42 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | FURIN | P09958 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25300505 | 0.98 | KDM1A (0.44) | MAPTKDM1AMAOBKCNH2RCOR1 | |
| Hydrochloric Acid SCHEMBL25308699 | 0.98 | KDM1A (0.44) | MAPTKDM1AMAOBKCNH2RCOR1 | |
| Hydrochloric Acid SCHEMBL25300504 | 0.98 | KDM1A (0.44) | MAPTKDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL9913849 | 0.79 | SLC6A4 (0.59) | MAPTMAOBSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9913891 | 0.79 | SLC6A4 (0.59) | MAPTMAOBSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL30230283 | 0.79 | TEAD4 (0.43) | MAPTMAOBSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL23951609 | 0.79 | KDM1A (0.42) | KDM1ASLC6A4SLC6A2SLC6A3EPHX2 | |
| SCHEMBL23951657 | 0.79 | TEAD4 (0.43) | MAPTMAOBSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL30182887 | 0.78 | SLC6A2 (0.57) | KDM1AMAOBKCNH2RCOR1SLC6A4 | |
| SCHEMBL20046785 | 0.78 | SLC6A2 (0.57) | KDM1AMAOBKCNH2RCOR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857404-B1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2017-08-23 | — | — | EP | disclosed |
| EP-2857404-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE AS KINASE INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2015-04-08 | — | — | EP | disclosed |