Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19263522 | 1.00 | RXFP1 (0.52) | RXFP1MAPTCA12CA1CA2 | |
| SCHEMBL16623045 | 1.00 | RXFP1 (0.52) | RXFP1MAPTCA12CA1CA2 | |
| SCHEMBL11891161 | 0.82 | TP53 (0.51) | RXFP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL20901706 | 0.82 | TSHR (0.55) | MEN1KMT2ALMNASMN1; SMN2MAPK1 | |
| SCHEMBL20901666 | 0.82 | TSHR (0.55) | MEN1KMT2ALMNASMN1; SMN2MAPK1 | |
| SCHEMBL1534257 | 0.82 | TDP1 (0.49) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL18010611 | 0.82 | TSHR (0.55) | MEN1KMT2ALMNASMN1; SMN2MAPK1 | |
| SCHEMBL24324308 | 0.81 | DPP4 (0.55) | MAPTCA12CA1CA2CA4 | |
| SCHEMBL11030162 | 0.81 | DPP4 (0.55) | MAPTCA12CA1CA2CA4 | |
| Hydrochloric Acid SCHEMBL17967158 | 0.81 | TSHR (0.54) | MEN1KMT2ALMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857404-B1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2017-08-23 | — | — | EP | disclosed |
| EP-2857404-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE AS KINASE INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2015-04-08 | — | — | EP | disclosed |