Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.68 |
| ▸ | RAB9A | P51151 | 8/20 | 0.68 |
| ▸ | NPC1 | O15118 | 7/20 | 0.68 |
| ▸ | APP | P05067 | 5/20 | 0.68 |
| ▸ | GLA | P06280 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | SNCA | P37840 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | RORC | P51449 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987260 | 0.93 | MAPT (0.63) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL2195913 | 0.93 | MAPT (0.63) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL1984426 | 0.92 | APP (0.84) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL1982573 | 0.92 | APP (0.62) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL1984424 | 0.92 | APP (0.84) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL12422070 | 0.92 | APP (0.84) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL1982572 | 0.92 | APP (0.62) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL12422217 | 0.91 | MAPT (0.81) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL12421915 | 0.89 | APP (0.85) | MAPTKDM4ERAB9ANPC1APP | |
| SCHEMBL1982961 | 0.89 | APP (0.85) | MAPTKDM4ERAB9ANPC1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338059-B1 | Ligands for aggregated tau molecules | WISTA LAB LTD (SG) | 2015-04-08 | — | — | EP | disclosed |