SCHEMBL12422217

SCHEMBL12422217

Cc1ccc(-c2nc3ccc(C)cc3s2)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 0.81
▸ KDM4E B2RXH2 8/20 0.81
▸ RAB9A P51151 8/20 0.81
▸ NPC1 O15118 7/20 0.81
▸ APP P05067 5/20 0.81
▸ GLA P06280 5/20 0.81
▸ GAA P10253 5/20 0.81
▸ SNCA P37840 1/20 0.77
▸ ALDH1A1 P00352 7/20 0.66
▸ HPGD P15428 5/20 0.66
▸ RORC P51449 2/20 0.66
▸ SMN1; SMN2 Q16637 6/20 0.63
▸ MEN1 O00255 4/20 0.63
▸ KMT2A Q03164 4/20 0.63
▸ LMNA P02545 2/20 0.63
▸ CASP3 P42574 1/20 0.63
▸ SENP8 Q96LD8 1/20 0.63
▸ SENP7 Q9BQF6 1/20 0.63
▸ SENP6 Q9GZR1 1/20 0.63
▸ TP53 P04637 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16623332 0.91 MAPT (0.68) MAPTKDM4ERAB9ANPC1APP
SCHEMBL13453290 0.90 APP (1.00) MAPTKDM4ERAB9ANPC1APP
SCHEMBL12355589 0.90 MAPT (0.72) MAPTKDM4ERAB9ANPC1APP
SCHEMBL2244143 0.90 APP (0.72) MAPTKDM4ERAB9ANPC1APP
SCHEMBL5349180 0.90 MAPT (0.72) MAPTKDM4ERAB9ANPC1APP
SCHEMBL492713 0.90 APP (1.00) MAPTKDM4ERAB9ANPC1APP
SCHEMBL2950103 0.90 APP (0.72) MAPTKDM4ERAB9ANPC1APP
SCHEMBL507097 0.89 MAPT (0.71) MAPTKDM4ERAB9ANPC1APP
SCHEMBL14205633 0.89 APP (0.65) MAPTKDM4ERAB9ANPC1APP
SCHEMBL13484314 0.89 APP (0.70) MAPTKDM4ERAB9ANPC1APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12018128-B2 Particle-dispersed polyimide precursor solution, method for producing porous polyimide film, and porous polyimide film FUJIFILM BUSINESS INNOVATION CORP. (JP) 2024-06-25 — — US disclosed
US-20220119596-A1 PARTICLE-DISPERSED POLYIMIDE PRECURSOR SOLUTION, METHOD FOR PRODUCING POROUS POLYIMIDE FILM, AND POROUS POLYIMIDE FILM FUJIFILM BUSINESS INNOVATION CORP. (JP) 2022-04-21 — — US disclosed
US-11034797-B2 Polyimide precursor composition, use thereof and polyimide made therefrom ETERNAL MATERIALS CO., LTD. (TW) 2021-06-15 — — US disclosed
US-20210079161-A1 POLYIMIDE PRECURSOR COMPOSITION, USE THEREOF AND POLYIMIDE MADE THEREFROM ETERNAL MATERIALS CO., LTD. (TW) 2021-03-18 — — US disclosed
WO-2020046991-A1 FASCIN BINDING COMPOUNDS FOR SPINOGENESIS SPINOGENIX, INC. (US) 2020-03-05 — — WO disclosed
US-20180134714-A1 COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS CASE WESTERN RESERVE UNIVERSITY 2018-05-17 — — US disclosed
US-9864322-B2 Image forming apparatus RICOH COMPANY, LTD. (JP) 2018-01-09 — — US disclosed
US-9714219-B2 Sulfonylaminobenzamide compounds NOVARTIS TIERGESUNDHEIT AG (CH) 2017-07-25 — — US disclosed
US-20160363886-A1 IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2016-12-15 — — US disclosed
US-20160363886-A1 IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2016-12-15 — — US disclosed
US-7403735-B2 Image formation apparatus using an electrophotographic process RICOH COMPANY, LTD. (JP) 2008-07-22 — — US disclosed
US-7375222-B2 2,4,6-Triamino-1,3,5-triazine derivative ASTELLAS PHARMA INC. (JP) 2008-05-20 — — US disclosed
US-7375222-B2 2,4,6-Triamino-1,3,5-triazine derivative ASTELLAS PHARMA INC. (JP) 2008-05-20 — — US disclosed
US-7365359-B2 Organic semiconductor material and organic semiconductor element DAI NIPPON PRINTING CO., LTD. (JP) 2008-04-29 — — US disclosed
EP-1689717-B1 SUBSTITUTED ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS GLAXO GROUP LTD (GB) 2007-12-26 — — EP disclosed
US-7255938-B2 Organic electroluminescent device and organic compound for use in organic electroluminescent device SANYO ELECTRIC CO., LTD. (JP) 2007-08-14 — — US disclosed
US-7183409-B2 Basic mono- and bisazo compounds CLARIANT FINANCE (BVI) LIMITED (VG) 2007-02-27 — — US disclosed
US-7183409-B2 Basic mono- and bisazo compounds CLARIANT FINANCE (BVI) LIMITED (VG) 2007-02-27 — — US disclosed
US-7175958-B2 Electrophotographic photoconductor, process for forming an image, image forming apparatus and process cartridge for the same RICOH COMPANY, LTD. (JP) 2007-02-13 — — US disclosed
US-7175958-B2 Electrophotographic photoconductor, process for forming an image, image forming apparatus and process cartridge for the same RICOH COMPANY, LTD. (JP) 2007-02-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134714-A1 COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS ALDH1A2, NR2E3, LRAT MAPT 755/4885KDM4E 4118/4885RAB9A 432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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