Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SCD | O00767 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987631 | 0.90 | MMP2 (0.65) | MAPTNPC1RAB9ALMNASCD | |
| SCHEMBL2194729 | 0.88 | MAPT (0.61) | MAPTNPC1RAB9ALMNASCD | |
| SCHEMBL2193898 | 0.88 | MAPT (0.55) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL2191507 | 0.87 | APP (0.71) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL12421986 | 0.86 | MAPT (0.68) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL21887622 | 0.85 | NPC1 (0.67) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL2195372 | 0.83 | MAPT (0.56) | MAPTNPC1RAB9ALMNASCD | |
| SCHEMBL2192885 | 0.82 | APP (0.70) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL15224059 | 0.81 | NPC1 (0.65) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL2192742 | 0.81 | MAPT (0.73) | MAPTNPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338059-B1 | Ligands for aggregated tau molecules | WISTA LAB LTD (SG) | 2015-04-08 | — | — | EP | disclosed |