Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849243 | 1.00 | JAK1 (0.42) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL17849195 | 0.93 | HSP90AA1 (0.35) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL16623474 | 0.93 | HSP90AA1 (0.35) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL16623536 | 0.93 | HSP90AA1 (0.35) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL16623551 | 0.92 | JAK1 (0.34) | JAK1JAK2TYK2JAK3ROCK2 | |
| SCHEMBL16623491 | 0.91 | JAK1 (0.34) | JAK1JAK2TYK2ROCK2 | |
| SCHEMBL16623472 | 0.90 | JAK1 (0.33) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL16623543 | 0.89 | JAK1 (0.38) | JAK1JAK2TYK2JAK3PRKAA1 | |
| SCHEMBL16623546 | 0.88 | JAK1 (0.33) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL16623529 | 0.86 | JAK1 (0.33) | JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |