Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623551 | 0.99 | JAK1 (0.34) | JAK1JAK2ROCK2TYK2ALOX15 | |
| SCHEMBL16623536 | 0.92 | HSP90AA1 (0.35) | JAK1JAK2TYK2 | |
| SCHEMBL16623474 | 0.92 | HSP90AA1 (0.35) | JAK1JAK2TYK2 | |
| SCHEMBL17849195 | 0.92 | HSP90AA1 (0.35) | JAK1JAK2TYK2 | |
| SCHEMBL16623472 | 0.91 | JAK1 (0.33) | JAK1JAK2TYK2 | |
| SCHEMBL16623510 | 0.91 | JAK1 (0.42) | JAK1JAK2ROCK2TYK2 | |
| SCHEMBL17849243 | 0.91 | JAK1 (0.42) | JAK1JAK2ROCK2TYK2 | |
| SCHEMBL16623543 | 0.90 | JAK1 (0.38) | JAK1JAK2TYK2PRKD1PRKD2 | |
| SCHEMBL16623456 | 0.90 | HCAR3 (0.36) | JAK1JAK2ROCK2HDAC8BRD4 | |
| SCHEMBL16623546 | 0.89 | JAK1 (0.33) | JAK1JAK2TYK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |