Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623464 | 0.99 | JAK1 (0.38) | JAK1JAK2HDAC8BRD4ALOX15 | |
| SCHEMBL16623488 | 0.91 | JAK1 (0.33) | JAK1JAK2 | |
| SCHEMBL16623582 | 0.89 | JAK1 (0.33) | JAK1JAK2 | |
| SCHEMBL16623512 | 0.88 | JAK1 (0.43) | JAK1JAK2BRD4 | |
| SCHEMBL16623555 | 0.88 | JAK1 (0.38) | JAK1JAK2HDAC8BRD4HCAR3 | |
| SCHEMBL16623440 | 0.87 | JAK2 (0.44) | JAK1JAK2BRD4 | |
| SCHEMBL16623528 | 0.87 | RAB9A (0.41) | JAK1JAK2HDAC8BRD4ALOX15 | |
| SCHEMBL16726651 | 0.87 | NPC1 (0.41) | JAK1JAK2BRD4KDM4E | |
| SCHEMBL16623521 | 0.86 | JAK1 (0.39) | JAK1JAK2KDM4E | |
| SCHEMBL16623567 | 0.86 | BRD4 (0.36) | JAK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |