Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18033526 | 0.81 | KCNH2 (0.33) | ALDH1A1HTR2CHTR2AKDM4EACHE | |
| SCHEMBL18034948 | 0.81 | MAPT (0.46) | MAPTMEN1ALDH1A1APPSNCA | |
| SCHEMBL16624014 | 0.78 | METAP1 (0.44) | MEN1ALDH1A1KMT2ASIGMAR1HTR2C | |
| SCHEMBL12367363 | 0.77 | DRD1 (0.47) | MAPTALDH1A1HTR2CHTR2AKDM4E | |
| SCHEMBL26768689 | 0.76 | METAP1 (0.44) | MAPTALDH1A1HTR2CHTR2AKDM4E | |
| SCHEMBL356453 | 0.74 | MAPT (0.51) | MAPTMEN1ALDH1A1APPSNCA | |
| SCHEMBL31147657 | 0.74 | MAPT (0.51) | MAPTMEN1ALDH1A1APPSNCA | |
| SCHEMBL5969900 | 0.74 | MAPT (0.51) | MAPTMEN1ALDH1A1APPSNCA | |
| SCHEMBL356454 | 0.74 | MAPT (0.51) | MAPTMEN1ALDH1A1APPSNCA | |
| SCHEMBL31167959 | 0.74 | MAPT (0.51) | MAPTMEN1ALDH1A1APPSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3053917-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nissan Chemical Industries, Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015050212-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日産化学工業株式会社 | 2015-04-09 | — | — | WO | disclosed |