Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12367363 | 0.80 | DRD1 (0.47) | METAP1KDM4EALDH1A1HTR2AHTR2C | |
| SCHEMBL18033524 | 0.80 | METAP1 (0.40) | METAP1ACHEKDM4EGAAALDH1A1 | |
| SCHEMBL18034953 | 0.80 | SIGMAR1 (0.48) | METAP1ACHEKDM4EGAAALDH1A1 | |
| SCHEMBL26768689 | 0.79 | METAP1 (0.44) | METAP1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16624009 | 0.78 | MAPT (0.43) | METAP1ACHEKDM4EALDH1A1ADAM17 | |
| SCHEMBL13015321 | 0.77 | ALDH1A1 (0.48) | METAP1ACHEKDM4EGAAALDH1A1 | |
| SCHEMBL18699828 | 0.76 | ADAM17 (0.44) | METAP1ACHEKDM4EGAAALDH1A1 | |
| SCHEMBL13521646 | 0.72 | DRD1 (0.57) | — | |
| SCHEMBL29557542 | 0.72 | DRD1 (0.57) | — | |
| SCHEMBL4320078 | 0.72 | HRH3 (0.59) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3053917-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nissan Chemical Industries, Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015050212-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日産化学工業株式会社 | 2015-04-09 | — | — | WO | disclosed |